Not only did John Romita's cover for Heart Throbs #56 (October-November 1958) serve as a splash page, it also got a third use as a story panel.
Hopalong Cassidy #119 (November 1956), Gene Colan and Joe Giella.
Ross Andru and Mike Esposito, Metal Men #3 (August-September 1963).same scene, different POV. Different character speaks different line, but with same intent.
Our Fighting Forces #78 (August 1963), Cover by Joe Kubert, interior by Jerry Grandenetti. Different POV , characters switch position, missing helmet.
Tim Holt #20 (November 1950), probably by Frank Bolle.
Splash panel used as cover, color change extensive.
Girls' Romances #41 (October-November 1956), Cover used as splash. Romita perhaps? Or maybe Sy Barry?