Frush opened her first studio in Chicago in the early 1940s. She created a a string of popular Calender Girls series: Liberty Belles, Sweethearts of Sports, Girls of Glamour and Glamour Round the Clock. In 1947, her Aquatour series, a dozen pin-ups all located in aquatic settings, broke all sales records.
Frush enjoyed sailing, canoeing, swimming, and playing tennis, and she would often incorporate sport themes into her work.
She sometimes signed her paintings with her married name "Mann".