Orson B. Lowell, the son of landscapist Milton H. Lowell, was born in 1871. He studied with the well-known anatomist, J. H. Vanderpoel, at the Art Institute of Chicago, Illinois. He moved from Chicago to New York in 1893. Known for the richness of his work in pen and ink, by 1907, he was employed at Life magazine, at that time a humor publication competing with Judge and Punch. He died in 1956.