The radio program aired from 1937 to 1952 and had a listening audience rated between 10 and 20 million people. Paramount made four BIG TOWN motion pictures. The TV show ran from 1950 to 1956, the first 2 years being telecast live.
Here is a story from issue #40, July 1956, written by John Broome with art by Manny Stallman and John Giunta.
Strange ad placement:
This issue contained a somewhat puzzling ad considering the readership of DC comics was probably close to 99% children. Certainly not many people who'd be doing the household grocery shopping.